报告题目:Self-assembled polymeric nanoparticles – from competitive kinetics to biomedical applications
开始时间:2018-11-27 13:30:002018-11-27 13:30:00
报告地点:华东理工大学化工学院实验十六楼110室
报 告 人:Prof. Liu YingProf. Liu Ying
主办单位:实验十六楼110室2018-11-27 13:30:00
备注:
 报告题目: Self-assembled polymeric nanoparticles – from competitive kinetics to biomedical applications
  
 开始时间: 2018-11-27 13:30:00
  
 报告地点: 实验十六楼110室
  
 报 告 人: Prof. Liu Ying
  
 主办单位: 华东理工大学化工学院
  
 备    注:

个人简介:刘颖博士现任伊利诺伊大学芝加哥分校副教授,博士导师,就职于化工系,生物药学系和生物工程。曾任中美药协中西部(SAPA-MW)主席。刘颖博士具有应用物理数学,化学,化工,生物制药等多个领域的丰富科研经验。 刘颖博士目前主要的研究项目是生物纳米技术在药物传播中的应用。 基于对分子过程的严格控制,此项纳米技术可以准确制定纳米粒子的物理化学和生物属性。刘颖博士的多个科研项目受到美国国防部,NIH,和国家自然基金的支持超过400万美金。现已有多个成果转化成为应用,刘颖博士有专利6个,核心期刊论文超过30篇,并著有关口服药物释放的书籍章节,有关微流体在生物检测的应用的书籍章节。刘颖博士曾获如下奖项: GraduateMentor Award (2017), 伊利诺伊大学年度学者奖(伊利诺伊大学最高学术奖)(2016年),国家自然基金事业奖 (2014年),工程学院最佳学术奖(2013年),伊利诺伊大学创业技术奖(2013年),校长发明发现奖(2012),对发展中地区最有益技术奖(2006年)。刘颖博士在普林斯顿就读期间获普林斯顿最高奖学金之一Howard Catherin Phillips 奖学金。


摘要:This research group is interested in understanding the competitive kinetics during molecular self-assembly to control and optimize particle formation. Two types of particles– toroidal-spiral particles (TSPs) and polymeric nanoparticles will be presented.The technology we have developed to generate TSPs is based on the self-assembly kinetics of drop sedimentation and interaction. During sedimentation in a miscible,viscous liquid, polymeric drops self-assemble into a reproducible toroidal-spiral shape,which could be solidified into solid particles by various means of polymer cross-linking.TSPs can be used as versatile carriers to deliver a combination of therapeutic agents of different sizes and manipulate individual drug release to reach best drug synergy for the treatment of complex diseases. Moreover, TSPs could also be used to encapsulate therapeutic cells for cell protection, local stimulation, and release.Manipulating non-equilibrium structures of the polymeric nanoparticles to achieve high drug loading is through kinetic control by a sophisticated combination of mixing and spray drying. We combined experimental and simulation tools to elucidate the self-assembly kinetics of polymeric micelles that control pharmaceutical nanoparticle physicochemical properties. By integrating microfluidic devices with synchrotron X-ray beam, the measurements with high temporal and special resolutions were achieve.

  
 


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