|报告题目:||Innovative polymer-based systems for controlled delivery of drugs|
|报 告 人:||刘尽尧教授|
Developing innovative engineering methodologies that allow for the preparation of precisely defined polymeric therapeutics by simple strategies has significant fundamental interest and enormous potential for medical applications. In this presentation, I will share three stories about using synthetic chemistry to prepare biomedical polymers with aims to improve the delivery of drugs including small molecules and biopharmaceuticals. The first story will cover some recent works we have done on extended oral drug delivery to treat infectious diseases by a single administration. We synthesize a triggerable tough hydrogel to serve as gastric-resident dosage forms which help to achieve continuous drug release up to 5 days after a single oral dose and significantly improved safety profile in a large animal model. The second story will focus on conjugating protein drugs with polymers for treating type-2 diabetes. We develop a modular method to synthesize precisely defined protein/peptide–polymer conjugates in a well-controlled manner of site–specific, stoichiometric and high yield, and show that a single subcutaneous injection of the resultant conjugates to mice reaches an extended glucose reduction up to 3 days. Lastly, I will introduce a versatile approach to prepare well-defined drug loaded nanoparticles via ring-opening polymerization of prodrug monomers for tumor chemotherapy. The obtained nanoparticles with ultra-high drug loading capacity demonstrate enhanced antitumor efficacy and reduced systemic toxicity in contrast to its free drug in a mouse model.