|报告题目:||Protein Engineering of Multi-functional Biomaterials for Regenerative Medicine|
|报 告 人:||Prof. Sarah C. Heilshorn|
报告题目：Protein Engineering of Multi-functional Biomaterials for Regenerative Medicine
报告人：Prof. Sarah C. Heilshorn，Stanford University
1998 B.Eng., Georgia Institute of Technology
2004 Ph.D., California Institute of Technology
2004-2006 Postdoctoral Fellow, University of California, Berkeley
2006-2014 Assistant Professor, Stanford University
2014-current Associate Professor, Stanford University
2015 University of Sydney International Research Collaboration Award
2017 Royal Society of Chemistry, elected fellow
2018 Young Talent Award, State Key Laboratory of Molecular Engineering of Polymers, China
Nat. Biotechnol., 2016; 34:752-759
Science, 2010; 327:547-552.
Cell, 2007; 129:565-577.
Adv. Mater., 2009; 21:4148-4152
Adv. Mater., 2012; 24:3923-3940.
Stem cell transplantation is a promising therapy for a myriad of debilitating diseases and injuries; however, current expansion and transplantation protocols are inadequate. My lab designs biomaterials to overcome these challenges using biomimetic, protein-engineering technology. By integrating protein science methodologies with simple polymer physics models, we manipulate the polypeptide chain interactions and demonstrate the direct ability to tune the material properties including hydrogel mechanics, cell-adhesion, and biodegradation. These materials have allowed us to identify matrix remodeling as a previously unknown requirement
for maintenance of stemness in neural progenitor cells within 3D expansion systems. Through a series of in vitro and in vivo studies, we demonstrate that protein-engineered hydrogels may significantly improve transplanted stem cell retention and regenerative function. Furthermore, many of the lessons learned about designing injectable biomaterials can be extended to design new bio-inks for 3D printing applications. While 3D printing has enormous potential for tissue engineering, few bio-inks are currently available to facilitate the printing of complex, cell-laden constructs. We demonstrate the design of customizable bio-inks that enable the printing of multiple cell types into distinct geometric forms.