|报告题目:||Biomaterials capable of cell membrane modulation and selective in vivo labeling for drug delivery applications|
|报 告 人:||Prof. Jianjun Cheng|
2015 Full Professor, University of Illinois at Urbana Champaign
2011 Associate Professor, University of Illinois at Urbana Champaign
2005 Assistant Professor, University of Illinois at Urbana Champaign
2004 Post Doctorate, MIT
2001 Ph.D., University of California, Santa Barbara
1996 M.S., Southern Illinois University
1993 B.S., Nankai University
PNAS, 2018, 115, 4903-4908.
J. Am. Chem. Soc., 2018, 140, 1235-1238.
Chem. Soc. Rev., 2017, 46, 6570-6599
Nat. Chem. Biol., 2017, 13, 415-424.
Nat. Commun., 2017, 8, 92.
Nat. Chem., 2017, 9, 614-622.
J. Am. Chem. Soc., 2016, 138, 9498-9507.
Nature, 2016, 530, 71-76.
I will present our work around design of helical polypeptides. I will report our design of helical, charged polypeptides, which has shown excellent cell membrane activity. By controlling the hydrogen bonding donor and acceptor properties, we can precisely tune the helicity of polypeptides. I will report the integration of Ring-opening metathesis polymerization and ring-opening polymerization of the amino acid N-carboxyanhydride to allow facile synthesis of amino acid N-carboxyanhydride was found and the polymerization of controlled by the brush polypeptide helices In the second portion of my talk, I will present sugar molecule mediated in vivo Cancer targeting.