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 报告题目: Inspiration from Fluorination: Chemical Biology Approaches to Probe Molecular Recognition Events in Biology
  
 开始时间: 2018-07-19 15:30:00
  
 报告地点: 实验一楼第一会议室
  
 报 告 人: Prof. William C. K. Pomerantz
  
 主办单位: 材料科学与工程学院
  
 备    注:

报告题目:Inspiration from Fluorination:  Chemical Biology Approaches to Probe Molecular Recognition Events in Biology

报告人:Prof. William C. K. Pomerantz

 

报告时间:719日(星期四 15:30-17:00

报告地点:实验一楼第一会议室

联系人:刘润辉

 

报告人介绍:

Biography :

2018 - present      Associate Professor, University of Minnesota, Twin Cities

2012 - 2018        Assistant Professor, University of Minnesota, Twin Cities

2008 - 2012        Post Doctorate, University of Michigan

2003 - 2008        Ph.D., University of Wisconsin-Madison, Madison, WI

1998 - 2002         B.S., Ithaca College, Ithaca NY

Angew. Chem. Int. Ed.,  2017, 56, 6440-44.                  

ACS Nano, 2017, 11, 5623-32.

Nat. Chem. Biol., 2016, 12, 860-6.                               

Nat. Protoc., 2016, 11, 1414-27.

Angew. Chem. Int. Ed., 2015, 54, 3735-9.                      

J. Am Chem. Soc.,  2011, 133, 13604-13.     

 

 

Abstract    

    Protein-protein interaction (PPI) inhibitor discovery has proven difficult due to the large surface area and dynamic interfaces.  To detect these interactions, the trace amounts of organic fluorine in biology has led scientists to benefit from this bioorthogonality and use fluorine to visualize biological phenomenon by magnetic resonance. In the first part of the talk, I will described our efforts to facilitate the early lead discovery rate of small molecules for PPIs using a rapid protein-based 19F NMR method for detecting protein-ligand interactions called PrOF NMR. In the second part of the talk, I will describe our molecular design efforts for creating new peptide-based 19F MRI agents.  I will present our research design strategy for developing highly fluorinated polyamides with tunable biological and environmental stability.