|报告题目:||Inspiration from Fluorination: Chemical Biology Approaches to Probe Molecular Recognition Events in Biology|
|报 告 人:||Prof. William C. K. Pomerantz|
报告题目：Inspiration from Fluorination: Chemical Biology Approaches to Probe Molecular Recognition Events in Biology
报告人：Prof. William C. K. Pomerantz
2018 - present Associate Professor, University of Minnesota, Twin Cities
2012 - 2018 Assistant Professor, University of Minnesota, Twin Cities
2008 - 2012 Post Doctorate, University of Michigan
2003 - 2008 Ph.D., University of Wisconsin-Madison, Madison, WI
1998 - 2002 B.S., Ithaca College, Ithaca NY
Angew. Chem. Int. Ed., 2017, 56, 6440-44.
ACS Nano, 2017, 11, 5623-32.
Nat. Chem. Biol., 2016, 12, 860-6.
Nat. Protoc., 2016, 11, 1414-27.
Angew. Chem. Int. Ed., 2015, 54, 3735-9.
J. Am Chem. Soc., 2011, 133, 13604-13.
Protein-protein interaction (PPI) inhibitor discovery has proven difficult due to the large surface area and dynamic interfaces. To detect these interactions, the trace amounts of organic fluorine in biology has led scientists to benefit from this bioorthogonality and use fluorine to visualize biological phenomenon by magnetic resonance. In the first part of the talk, I will described our efforts to facilitate the early lead discovery rate of small molecules for PPIs using a rapid protein-based 19F NMR method for detecting protein-ligand interactions called PrOF NMR. In the second part of the talk, I will describe our molecular design efforts for creating new peptide-based 19F MRI agents. I will present our research design strategy for developing highly fluorinated polyamides with tunable biological and environmental stability.