|报告题目:||Biological Control Systems: Systems Biology of Diseases and the Design of Effective Treatments|
|报 告 人:||美国特拉华大学Babatunde A. Ogunnaike院士|
“Babatunde A. Ogunnaike教授 “名誉教授”专家受聘仪式暨学术报告会”
The mammalian organism maintains stable, efficient and “near-optimal” performance and homeostasis in the face of external and internal perturbations via distinct biological systems ranging from the large-scale physiological (nervous, endocrine, immune, circulatory, respiratory, etc.), to the cellular (growth and proliferation regulation, DNA damage repair, etc.), and the sub-cellular (gene expression, protein synthesis, metabolite regulation, etc). “Biological Control Systems,” a sub-topic of Control Theory, arises from a control engineering perspective of the function, organization, and coordination of these multi-scale biological systems and the control mechanisms that enable them to carry out their functions effectively.
In this presentation, we will provide an overview of how physiological life is made possible by control, and demonstrate the usefulness of a control engineering perspective of pathologies for diagnosis, design, and implementation of effective treatments. The concepts and principles will be illustrated using three specific examples with significant research and clinical implications: Ca++ Regulation (see Fig 1); TGF-β and prostate cancer; and Platelet Deficiency Control.